Bile Acid and Gut Microbiota Alterations in Aging Humans, 200 Participants

Table 1_The alteration of bile acids and gut microbiota is associated with intestinal barrier dysfunction and inflammaging in human.docx is a research dataset by Yumei Xu, last updated April 15, 2026. It contains data from a cross-sectional study of 100 elderly and 100 young participants, quantifying fecal and serum bile acids via LC-MS/MS, assessing gut microbiota via 16S rRNA sequencing, and measuring cytokine levels via ELISA.

Use Cases

• Correlating bile acid profiles with age based on quantified primary and secondary bile acids.
• Investigating associations between gut microbiota composition and markers of intestinal barrier dysfunction.
• Analyzing relationships between specific bile acid changes and inflammatory cytokine levels like IL-6 and TNF-α.
• Studying shifts in microbial functions, such as 7α-dehydroxylation capacity, across age groups.

Strengths

• Data from a controlled study with 200 participants (100 elderly, 100 young).
• Multiple analytical methods used: LC-MS/MS for bile acids, 16S rRNA sequencing for microbiota, and ELISA for cytokines.
• Explicitly measures key biomarkers like cholic acid, lithocholic acid, LPS, P21, IL-6, and TNF-α.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The cross-sectional design, as noted in the description, prevents establishing causal relationships.

Provenance

Source

Yumei Xu via figshare.

Collection Method

Data gathered from human participants via LC-MS/MS, 16S rRNA gene sequencing, and ELISA assays.

Time Range

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Freshness

Last updated 2026-04-15 05:42:24; freshness should be verified.

Geography

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