Meta-Analysis of GNRI and Mortality Risk After TAVR in 9,647 Patients

This meta-analysis pools data from 13 cohort studies involving 9,647 patients to assess the association between the Geriatric Nutritional Risk Index (GNRI) and mortality after transcatheter aortic valve replacement (TAVR). It reports a pooled hazard ratio of 1.90 for all-cause mortality associated with low pre-procedural GNRI.

Use Cases

• Validate the pooled hazard ratio (HR = 1.90) for low GNRI and all-cause mortality using the reported confidence intervals and I² statistic.
• Analyze subgroup differences in effect size, such as between prospective and retrospective studies (p = 0.04).
• Conduct meta-regression to explore the influence of covariates like age, sex, or STS score on the reported hazard ratio.

Strengths

• Aggregates data from 13 distinct cohort studies.
• Based on a pooled sample of 9,647 patients.
• Reports specific statistical measures including a hazard ratio of 1.90 with a 95% CI of 1.60–2.26 and I² = 43%.

Limitations

• The underlying raw patient-level data is not provided, only aggregated study results.
• The dataset is a 16.1 KB document summarizing findings, not a primary data table for direct analysis.
• Findings are specific to the TAVR patient population and the GNRI metric.

Provenance

Source

Systematic search of PubMed, Embase, and Web of Science.

Collection Method

Meta-analysis of observational studies using random-effects models.

Freshness

Last updated March 20, 2026.