Association of HbA1c Levels with In-Stent Restenosis in 6,297 CAD Patients

6,297 coronary artery disease patients following percutaneous coronary intervention were studied to examine the association between glycated hemoglobin (HbA1c) levels and in-stent restenosis (ISR) risk. The retrospective study, authored by Yuyang Lei and last updated in April 2026, found a non-linear relationship, with 1,305 individuals (20.72%) diagnosed with ISR. Higher HbA1c levels were significantly linked to greater ISR risk, with a threshold effect identified at an HbA1c level of 7.8%.

Use Cases

• Modeling the non-linear risk relationship between HbA1c levels and ISR incidence based on the described threshold effect analysis.
• Training predictive models for post-PCI restenosis risk using patient HbA1c levels and other clinical variables mentioned in the stratified analyses.
• Conducting meta-analyses or validation studies on glycemic control and cardiovascular stent outcomes using the reported odds ratios and cohort statistics.

Strengths

• Study includes a substantial cohort of 6,297 patients, providing a solid sample size for analysis.
• Results include specific statistical measures, such as an odds ratio of 1.70 for patients with HbA1c ≥6.5% and a defined threshold effect at 7.8%.
• Analysis employed adjusted logistic regression and generalized additive models (GAM), suggesting methodological rigor.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (23.8 KB), which may indicate it contains only summary results rather than the full patient-level data.
• The temporal and geographic coverage of the patient cohort is not specified, which may limit generalizability assessment.

Provenance

Source

Yuyang Lei

Collection Method

Retrospective clinical study of patient records.

Time Range

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Freshness

Last updated 2026-04 23 04:19:14; freshness should be verified.

Geography

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