Meta-Analysis of Remimazolam and Delirium Risk in Surgical Patients

A systematic review and meta-analysis aggregating data from 30 clinical trials, including 25 RCTs, investigating the association between the anesthetic remimazolam and postoperative delirium. The analysis includes 5,561 total patients and was conducted by Ziyu Zhu, with data searched up to December 10, 2025. It compares delirium incidence, postoperative nausea and vomiting, respiratory depression, extubation time, and hospital stay length between remimazolam and non-remimazolam groups.

Use Cases

• Compare delirium risk profiles between anesthetic agents based on the pooled incidence rates reported.
• Analyze secondary outcomes like postoperative nausea and vomiting rates associated with remimazolam use.
• Investigate effect modification by anesthesia type, such as general anesthesia, on delirium risk.
• Assess the relationship between prolonged remimazolam infusion and emergence delirium in pediatric populations.

Strengths

• Aggregates data from 30 trials, including 25 randomized controlled trials.
• Includes a total patient population of 5,561 individuals for primary outcome analysis.
• Conducts subgroup and meta-regression analyses on factors like age, surgery type, and assessment methods.

Limitations

• The dataset is a 109.2 KB document; the underlying raw trial data is not provided.
• Column-level documentation for any extracted data is absent; field semantics must be inferred from the manuscript.
• The temporal coverage of the included studies is not specified beyond the search cutoff date.

Provenance

Source

Systematic review of PUBMED, EMBASE, WEB OF SCIENCE, and Cochrane Library databases.

Collection Method

Meta-analysis of published clinical trial results.

Freshness

Last updated 2026-05-11 05:28:33