Pediatric Fever of Unknown Origin Etiologies from a Ten-Year Chinese Study

442 pediatric patients from a ten-year retrospective study at Fudan University Children's Hospital define the etiological spectrum of Fever of Unknown Origin (FUO). The data details clinical characteristics, immune phenotypes, laboratory parameters, and treatment responses for autoinflammatory diseases like PFAPA (n=135) and SURF (n=72).

Use Cases

• Analyze the distribution of etiologies like infectious diseases (20.6%) and autoinflammatory diseases (n=291) across the 442-patient cohort.
• Model the relationship between clinical features (e.g., fever episode intervals, systemic symptoms) and SURF subtypes (periodic vs. non-periodic).
• Compare treatment response rates, such as corticosteroid efficacy (90.9% aborting PFAPA episodes) and OM-85 clinical benefit (65.0%), across different conditions.
• Investigate laboratory parameter patterns (elevated CRP/ESR, neutrophilia, lymphopenia) during attacks for PFAPA and SURF patients.

Strengths

• Includes 442 pediatric patient cases with at least one-year follow-up data.
• Provides specific counts for key etiologies: 135 PFAPA cases and 72 SURF cases.
• Captures a ten-year temporal range of clinical data from 2014 to 2024.

Limitations

• Small sample size of 442 patients limits generalizability and statistical power for rare subtypes.
• Single-center study from one Chinese hospital introduces geographic and institutional bias.
• Column names and exact data structure are unknown, complicating direct analysis.

Provenance

Source

Retrospective study at Fudan University Children's Hospital.

Collection Method

Retrospective analysis of pediatric FUO cases.

Time Range

2014 to June 2024.

Freshness

Data covers up to June 2024, with the dataset last updated in March 2026.

Geography

China (single hospital in Shanghai).