Genetic Architecture of Parkinson's Disease in Mexico: A Systematic Review

Mexico-focused systematic review synthesizing genetic studies of Parkinson's disease from 2004 to February 2025. The work by Oscar Arias-Carrión analyzes 24 studies involving 7,048 participants (3,367 patients and 3,781 controls) to identify 27 genes and 71 variants associated with the disease. It was last updated in March 2026 and is shared under a CC-BY-4.0 license.

Use Cases

• Identify population-specific genetic risk variants for Parkinson's disease based on the review of 27 genes and 71 variants.
• Compare genetic association patterns in Mexican cohorts to other global populations based on reported loci like PRKN, SNCA, and GBA1.
• Investigate functional pathways implicated in Parkinson's disease, such as mitochondrial quality control and lysosomal processes, based on the integrated analysis.
• Design ancestry-aware genomic studies for Parkinson's disease based on the review's assessment of methodological heterogeneity and ancestry modeling gaps.

Strengths

• Systematic methodology following PRISMA 2020 guidelines and quality appraisal using the Q-Genie instrument.
• Harmonized data covering 24 studies and 7,048 participants, providing a consolidated view of the research landscape.
• Functional interpretation incorporates Gene Ontology, WikiPathways, and network-based analyses.

Limitations

• The dataset is a 157.5 KB DOCX document, indicating a limited scope focused on review text rather than raw genetic data.
• Row count and column-level documentation are absent; field semantics must be inferred from the text after download.
• The review notes substantial methodological heterogeneity and limited ancestry-aware analyses in the underlying studies.

Provenance

Source

Oscar Arias-Carrión via figshare

Collection Method

Systematic literature review of original studies published between 2004 and February 2025.

Time Range

Studies published between 2004 and February 2025.

Freshness

Last updated 2026-03-17 13:08:42

Geography

Mexico