Table 1_The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Al

A 2026 systematic review and meta-analysis by Ana Flavia F. Ferreira, evaluating the effects of microglial depletion via CSF1R inhibitors in preclinical models of Alzheimer's and Parkinson's disease. The analysis synthesizes results from 26 Alzheimer's disease and 17 Parkinson's disease studies. The document is a 49.4 KB text file summarizing neuroprotective outcomes, behavioral results, and pathological changes.

Use Cases

• Conducting secondary meta-analysis based on synthesized results from 43 preclinical studies.
• Identifying research gaps based on the noted lack of post-onset intervention studies.
• Evaluating the impact of depletion protocol duration based on reported trends for longer protocols.
• Analyzing heterogeneity in behavioral outcomes based on the contradictory results described.

Strengths

• Includes a formal systematic review registration identifier (CRD420251075163).
• Synthesizes a defined number of studies: 26 for Alzheimer's and 17 for Parkinson's disease models.
• Explicitly compares outcomes for two distinct neurodegenerative diseases.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description notes high heterogeneity and variability among the included studies as a clear limitation.

Provenance

Source

Ana Flavia F. Ferreira via figshare.

Collection Method

Systematic review and meta-analysis of published preclinical studies.

Time Range

Publication date of the review is 2026; temporal coverage of included studies is not specified.

Freshness

Last updated 2026-03-17 13:04:53; freshness should be verified.

Geography

Spatial coverage is not specified.