Table 1_The influence of fluoxetine on the blood pressure: a meta-analysis of randomized c

A meta-analysis document summarizing the results of randomized controlled trials investigating the effect of fluoxetine on blood pressure. The analysis includes five RCT arms encompassing 538 participants and was conducted by Deyun Huang, with results published on figshare in 2026. It reports pooled estimates for systolic and diastolic blood pressure changes using a random-effects model.

Use Cases

• Reviewing evidence on fluoxetine's cardiovascular effects based on the meta-analysis results
• Informing clinical trial design for antidepressant safety studies based on the methodological approach described
• Supporting literature reviews on SSRI side effects using the compiled findings from multiple RCTs

Strengths

• The analysis is based on a systematic review of randomized controlled trials, a gold-standard study design.
• Results include specific weighted mean differences with 95% confidence intervals (e.g., SBP WMD: 7.47 mmHg).
• Includes subgroup analysis based on treatment duration (e.g., trials lasting 12 weeks or less).

Limitations

• The document is a summary (18.7 KB DOCX) and does not contain the underlying raw trial data.
• The analysis notes substantial heterogeneity and a limited number of included studies (five RCT arms).
• Column-level documentation for any potential underlying data is absent; field semantics must be inferred.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of records from Scopus, Web of Science, Embase, and PubMed/MEDLINE up to July 28, 2025.

Freshness

Last updated 2026-05-28 06:17:17; freshness should be verified.