Table 1_The inhibitory effect of hepatic cancer energy metabolism on immune checkpoint the

Xin Li's dataset on figshare, last updated April 13, 2026, presents results from an integrated single-cell RNA-seq analysis of hepatocellular carcinoma (HCC) before and after immune checkpoint inhibitor therapy. The 10.0 KB XLSX file contains findings on metabolic reprogramming, prognostic model construction, and validation experiments targeting LDHA. The data supports the conclusion that dual targeting of LDHA and PD-1 enhances antitumor efficacy.

Use Cases

• Developing prognostic models for hepatocellular carcinoma based on pyruvate metabolism gene signatures described in the study.
• Analyzing cell-cell communication signaling pathways, such as SPP1–CD44 and APOA1–ABCA1, identified via CellChat.
• Investigating transcription factor regulatory networks (e.g., MYC, SP5) in HCC using pySCENIC inference results.
• Validating in vitro and in vivo therapeutic combinations, like (R)-GNE-140 with PD-1 blockade, using experimental assay data.

Strengths

• Data is derived from integrated single-cell RNA-seq sources (GEO, Mendeley) and TCGA data, suggesting multi-source validation.
• Includes results from functional validation assays (CCK8, Transwell) and in vivo xenograft experiments.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (10.0 KB), indicating it likely contains summary results rather than raw sequencing or expression data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

Author Xin Li, published on the figshare platform.

Collection Method

Integrated analysis of public single-cell RNA-seq data (GEO, Mendeley) using Seurat, AUCell, pySCENIC, CellChat, and Monocle, combined with TCGA data for model building.

Time Range

Temporal coverage of the underlying source data is not specified.

Freshness

Last updated 2026-04-13 05:21:20; freshness should be verified as this is a future date.

Geography

Spatial coverage is not specified.