Periodontitis Epithelial Repair Gene Expression Data

A 10.5 KB Excel file from a 2026 study by Yulong Zhang, containing data on the LAMB3–ITGA6 axis in epithelial repair. The dataset supports findings from single-cell sequencing of gingival epithelium in periodontitis patients and in vitro keratinization models.

Use Cases

• Analyze gene expression patterns from single-cell sequencing to identify epithelial subpopulations involved in repair.
• Investigate the correlation between LAMB3–ITGA6 axis expression and cytokeratin family gene regulation in knockdown/overexpression groups.
• Model the effect of retinol and BMS493 treatments on keratinization promotion and inhibition in human oral keratinocytes.
• Validate wound healing acceleration and cytokeratin 8 expression changes using data from the mouse dorsal skin wound model.

Strengths

• Data is derived from single-cell sequencing, providing high-resolution gene expression profiles.
• Includes experimental validation from both in vitro cellular models and an in vivo mouse wound model.
• Released under a permissive CC BY 4.0 license for broad reuse.

Limitations

• The dataset is very small at 10.5 KB, indicating limited scope and likely a summary table rather than raw sequencing data.
• Unknown row and column counts prevent assessment of data volume and feature diversity.
• Sample data and specific column names are unavailable, complicating direct analytical use.

Provenance

Source

figshare, authored by Yulong Zhang.

Collection Method

Single-cell sequencing of gingival epithelium from periodontitis patients, combined with in vitro keratinization models and in vivo mouse experiments.

Time Range

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Freshness

Last updated March 25, 2026.

Geography

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