Neutrophil-to-Lymphocyte Ratio and Mortality in 532 ANCA-Associated Vasculitis Patients

532 patients diagnosed with ANCA-associated vasculitis between June 2012 and June 2024 were studied to assess the biomarker NLR. The retrospective analysis from Tianjin Medical University General Hospital links NLR levels to organ involvement, all-cause mortality, and end-stage renal disease. Researcher Yunan Li identified a nonlinear mortality risk threshold at an NLR of 10.

Use Cases

• Model the nonlinear relationship between NLR and all-cause mortality using the identified threshold of 10 for risk stratification.
• Assess associations between NLR and specific organ involvement features like fever and renal dysfunction at diagnosis.
• Perform subgroup analysis on infection-related mortality proportions between high and low NLR patient groups.
• Validate NLR as an independent risk factor for adverse outcomes through multivariable-adjusted Cox regression.

Strengths

• Clinical data from 532 patients provides a substantive cohort for analysis.
• Study employs multiple analytical methods including logistic regression, Cox regression, and Kaplan-Meier survival analysis.
• Clear temporal coverage from June 2012 to June 2024 offers over a decade of patient follow-up.

Limitations

• Data is presented only in a 66.0 KB PDF, limiting direct computational analysis of the underlying tabular data.
• Sample is from a single hospital in China, which may limit geographic generalizability.
• The retrospective study design may introduce biases not present in a prospective trial.

Provenance

Source

Tianjin Medical University General Hospital

Collection Method

Retrospective study of patient records.

Time Range

June 2012 to June 2024

Freshness

Data covers patients up to June 2024, with the record last updated in March 2026.

Geography

China