Table 1_The pathological Huntingtin CAG triplet expansion differentially affects the diagn

European data from the Enroll-HD study analyzed the frequency of autoimmune diseases in 10,594 Huntington's disease mutation carriers compared to 2,477 control participants. The dataset, authored by Moritz Heyd and last updated in May 2026, contains results on how the pathological CAG triplet expansion in the HTT gene differentially affects the risk of specific autoimmune conditions like Hashimoto thyroiditis and psoriasis.

Use Cases

• Analyze the association between CAG repeat length and autoimmune disease risk based on the reported odds ratios.
• Investigate subgroup differences in autoimmune disease frequency (endocrine vs. dermatological) among Huntington's disease mutation carriers.
• Model the relationship between genetic mutation size and specific autoimmune conditions like psoriasis or Hashimoto thyroiditis.
• Study the distribution of ICD-10 coded comorbidities within a large clinical cohort for Huntington's disease.

Strengths

• Includes a large cohort of 10,594 Huntington's disease mutation carriers and 2,477 control participants.
• Provides specific odds ratios and confidence intervals for disease associations, such as 0.69 for Hashimoto thyroiditis and 1.27 for psoriasis.
• Data is derived from the structured Enroll-HD periodic dataset and uses ICD-10 codes for disease classification.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 4.3 MB file size suggests the dataset is relatively small, potentially limiting the granularity of analysis.

Provenance

Source

Enroll-HD periodic dataset #5 (European sites).

Collection Method

Analysis of comorbidities coded using abbreviated ICD-10 within the clinical dataset.

Time Range

null

Freshness

Last updated 2026-05-08 05:51:30; freshness should be verified.

Geography

European sites.