Meta-Analysis of Lung Immune Prognostic Index in Urological Cancers

A 2026 systematic review and meta-analysis synthesizes findings from 13 studies encompassing 19 cohorts and 5,304 patients. It quantifies the association between Lung Immune Prognostic Index categories and survival outcomes in renal cell, urothelial, and prostate cancers. The study provides hazard ratios for overall and progression-free survival across different risk groups.

Use Cases

• Validate the prognostic gradient of LIPI categories (good/intermediate/poor) for overall survival in new urological cancer cohorts.
• Compare hazard ratio estimates for progression-free survival across different tumor types (renal cell carcinoma, urothelial carcinoma, prostate cancer).
• Assess the consistency of LIPI's association with survival outcomes in immune checkpoint inhibitor-treated patient subgroups.
• Use reconstructed pseudo-individual patient data from Kaplan-Meier curves for secondary survival modeling.

Strengths

• Aggregates data from 13 studies representing 5,304 patients, providing a substantial evidence base.
• Follows PRISMA guidelines with a prospectively registered protocol, ensuring methodological rigor.
• Reports specific hazard ratios with confidence intervals for overall and progression-free survival across LIPI categories.

Limitations

• The underlying data is aggregated from published studies; original patient-level data is not included.
• As a systematic review, findings are dependent on the quality, heterogeneity, and publication bias of the included primary studies.
• The 7.0 MB DOCX file contains textual analysis; structured tabular data for direct computational use is unavailable.

Provenance

Source

Systematic review of PubMed, Embase, and Cochrane Library databases.

Collection Method

Meta-analysis of eligible cohort studies and trials using random-effects models with REML and Hartung-Knapp adjustment.

Time Range

Studies published through October 2025.

Freshness

Literature search conducted through October 2025; record last updated March 2026.

Geography

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