BMI1 Expression and Pregnancy Outcomes in Endometrial Receptivity Study

Clinical data from a study investigating the epigenetic regulator BMI1 as a biomarker for endometrial receptivity. The dataset includes measurements from 117 patient tissue samples (78 elective abortion, 39 spontaneous abortion) and a 2-year follow-up cohort of 50 infertile patients. Author Meili Liu published this research data on figshare in April 2026.

Use Cases

• Predict spontaneous abortion status using BMI1 expression levels measured by IHC, qPCR, or western blot.
• Correlate BMI1-positive/negative status with clinical outcomes like bio-chemical pregnancy, clinical pregnancy, and live birth rates.
• Analyze relationships between BMI1 expression and upstream/downstream pathway regulators (PR, E6AP, GATA6, NANOG).
• Validate the diagnostic utility of BMI1 for endometrial receptivity via ROC curve analysis metrics.
• Model the association between BMI1 localization (e.g., endometrial epithelium) and reproductive outcomes.

Strengths

• Includes data from 117 patient tissue samples with defined clinical groups.
• Contains multi-method validation of BMI1 levels (IHC, qPCR, western blot).
• Links biomarker data to 2-year clinical follow-up outcomes for 50 infertile patients.

Limitations

• Small sample size of 117 tissue samples and 50 follow-up patients limits statistical power for some analyses.
• Geographic and demographic coverage of the patient cohort is not specified, potentially limiting generalizability.
• Dataset is very small at 9.0 KB, indicating limited raw data or primarily summary results.

Provenance

Source

figshare, uploaded by author Meili Liu.

Collection Method

Endometrial tissues collected from patients; BMI1 levels measured via immunohistochemistry, quantitative real-time PCR, and western blot.

Time Range

Study period not specified; clinical follow-up covered two years.

Freshness

Data reflects study findings current as of the April 2026 publication date.

Geography

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