PfSR-X2 Knockdown Effects on Plasmodium falciparum Gene Expression

1.3 MB of transcriptomic data from a study investigating the RNA-binding protein PfSR-X2 in the human malaria parasite Plasmodium falciparum. The dataset, created by Ye Hu and last updated in May 2026, includes results from RNA sequencing and RNA immunoprecipitation sequencing experiments on a conditional knockdown parasite line.

Use Cases

• Identify stage-specific gene expression changes based on PfSR-X2 knockdown transcriptomic analysis
• Analyze perturbations to the rif multigene family and ApiAP2-associated pathways mentioned in the results
• Examine PfSR-X2-associated transcripts, including those encoding antigenically variant proteins
• Investigate limited alternative splicing changes detected at the schizont stage

Strengths

• Data is derived from CRISPR-Cas9-mediated genome editing and conditional knockdown experiments
• Includes results from both RNA sequencing and RNA immunoprecipitation sequencing
• Released under the CC-BY-4.0 license for open reuse

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Generated via CRISPR-Cas9-mediated genome editing, growth assays, Giemsa-stained blood smears, RNA sequencing, and RNA immunoprecipitation sequencing.

Freshness

Last updated 2026-05-26 08:28:52; freshness should be verified