SIRT1-p53 Axis and Ferro-Aging in Preeclampsia Placental Dysfunction

Placental SIRT1 expression data linked to senescence and iron dyshomeostasis in preeclampsia. The dataset, authored by Rong Hu and shared under CC-BY-4.0, was last updated on June 3, 2026. Its 5.0 MB size suggests a small-scale, focused collection of experimental results.

Use Cases

• Investigate the relationship between SIRT1 expression and cellular senescence based on described senescence-associated features.
• Model the interaction between iron dyshomeostasis and placental aging based on the described ferro-aging-like pathogenic program.
• Analyze trophoblast functional capacity (proliferation, migration, invasion) in relation to SIRT1 knockdown or activation.
• Study the role of the SIRT1-p53 axis as an upstream regulator linking iron imbalance to senescence.

Strengths

• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.
• Focus on a specific molecular axis (SIRT1-p53) provides a clear research context.
• Last updated date of 2026-06-03 indicates recent availability.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 5.0 MB file size suggests a relatively small dataset.

Provenance

Source

Rong Hu via figshare

Collection Method

Likely contains experimental results from a study on placental senescence.

Freshness

Last updated 2026-06-03 05:15:57