Thymelaea Hirsuta Extract Effects on NLRP3 Inflammasome Activation

A dataset from figshare by Seongjong Lee, last updated April 2026. It contains experimental results on the inhibitory effects of a plant extract on NLRP3 inflammasome activation in human and murine cell lines. The data likely includes measurements of IL-1β secretion, cell viability, and protein expression from Western blot analysis.

Use Cases

• Analyze dose-response relationships of Thymelaea hirsuta extract on IL-1β secretion based on ELISA results mentioned in the description
• Model the effect of plant extracts on NLRP3 ATPase activity based on the described experimental mechanism
• Compare inflammatory response inhibition between ATP and nigericin stimulation methods described in the study

Strengths

• Data is associated with a detailed experimental methodology described in the background
• Results include specific concentration levels tested (e.g., 1, 10, 50, and 100 μg/mL)
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (33.0 KB), indicating limited scope

Provenance

Source

figshare, author Seongjong Lee

Collection Method

Data likely generated from laboratory experiments on THP-1 and J774A.1 cell lines using methanol extraction, UPLC-QTOF/MS analysis, ELISA, and Western blot.

Time Range

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Freshness

Last updated 2026-04 05:44:19; freshness should be verified

Geography

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