Thyroid Autoimmunity and Cardiometabolic Risk in Women with Polycystic Ovary Syndrome

1,300 women with confirmed polycystic ovary syndrome (PCOS) were analyzed in a cross-sectional study to evaluate associations between thyroid autoimmunity and cardiometabolic or androgenic severity. The dataset, authored by Natalia Piórkowska and last updated in 2026, likely contains clinical and laboratory measurements such as thyroid antibodies, lipid profiles, and glucose tolerance test results. Associations were assessed using age-adjusted Firth logistic regression models.

Use Cases

• Assessing the relationship between thyroid autoimmunity and lipid profiles based on the triglyceride-to-HDL cholesterol ratio endpoint.
• Evaluating the link between thyroid antibody levels and impaired glucose tolerance based on the 120-minute OGTT glucose endpoint.
• Comparing cardiometabolic risk factors across different definitions of thyroid autoimmunity (e.g., high-titer anti-TPO) mentioned in the methodology.
• Conducting sensitivity analyses on clinical associations, such as restricting to euthyroid participants, as described in the study.

Strengths

• Includes a cohort of 1,300 women with confirmed PCOS, providing a substantial sample size.
• Employs pre-specified, rigorous exposure definitions (TAI_A, TAI_B, TAI_C) and statistical methods like Firth logistic regression.
• Contains results from sensitivity analyses, including restriction to euthyroid participants and trimming of extreme values.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (7.6 KB), indicating limited scope, likely containing summary results rather than raw patient-level data.

Provenance

Source

figshare

Collection Method

Cross-sectional analysis of a source dataset of women with PCOS.

Freshness

Last updated 2026-05-01 04:14:20; freshness should be verified.