TLN1-NGFR Interaction in Castration-Resistant Prostate Cancer: Research Article

Sixin Li published a research article on figshare on 2026-04-23, licensed under CC-BY-4.0. The 65.6 KB document details a study investigating the role of Talin-1 (TLN1) in castration-resistant prostate cancer (CRPC). The research includes data from mass spectrometry of patient serum, immunohistochemistry on 76 clinical tissue samples, and functional assays on CRPC cell lines.

Use Cases

• Studying the molecular mechanism of castration-resistant prostate cancer based on the described TLN1/NGFR axis.
• Validating potential biomarkers for prostate cancer progression based on TLN1 expression data from clinical samples.
• Investigating signaling pathways like PI3K-AKT and MAPK in cancer based on the described Western blot analyses.
• Exploring protein-protein interactions in cancer biology based on the molecular docking and co-immunoprecipitation results.

Strengths

• Includes data from 76 clinical tissue samples (59 PCa, 17 benign prostatic hyperplasia).
• Research methodology is detailed, covering mass spectrometry, functional assays, and in vivo models.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Dataset is a 65.6 KB DOCX file, suggesting it is a research article or summary rather than a primary data repository.
• Row count and column-level documentation are absent; underlying data tables are not directly accessible.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Sixin Li via figshare.

Collection Method

Research methods include mass spectrometry, immunohistochemistry, qPCR, Western blot, functional cell assays, and a nude mouse xenograft model.

Freshness

Last updated 2026-04-23 05:35:41; freshness should be verified.