Table 1_Towards an optimized approach for de-labeling penicillin allergy: comparison betwe

A clinical study dataset compares the performance of the PEN-FAST and PEN-FAST+ scores for identifying low-risk penicillin allergies. The research involved 288 patients with suspected beta-lactam allergy, of which 245 reported a penicillin allergy history. Results show PEN-FAST+ had a significantly higher AUC (0.810 vs. 0.639) and NPV (96.59% vs. 93.75%) than the original PEN-FAST score.

Use Cases

• Benchmarking diagnostic score performance based on AUC and NPV metrics reported in the study.
• Evaluating patient selection strategies for penicillin provocation tests based on risk score comparisons.
• Analyzing misclassification rates for immediate, delayed, and unknown timing hypersensitivity reactions.
• Informing hospital resource allocation for allergy work-ups based on the reported accuracy improvements.

Strengths

• Includes results from 288 patients studied for suspected beta-lactam allergy.
• Provides direct comparison of two validated clinical scores (PEN-FAST and PEN-FAST+) with statistical significance (p < 0.001).
• Reports specific performance metrics: AUC of 0.810 for PEN-FAST+ and NPV of 96.59%.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the single Italian cohort studied.

Provenance

Source

Giada Sambugaro via figshare.

Collection Method

Retrospective evaluation and comparison of diagnostic scores in a patient cohort.

Freshness

Last updated 2026-05-29 06:07:39; freshness should be verified.

Geography

Italian cohort.