Amantadine Toxicokinetics and Postmortem Redistribution in Male Rats

An integrated investigation of amantadine toxicokinetics and postmortem redistribution was conducted in male rats. The dataset likely contains drug concentration measurements in blood and nine tissues over 96 hours, following controlled oral doses and postmortem storage conditions. It was authored by Lingxiao Wang and last updated in March 2026.

Use Cases

• Modeling postmortem drug redistribution based on multi-tissue concentration data.
• Analyzing dose-dependent toxicokinetics based on low, medium, and high dose groups.
• Investigating the influence of storage temperature on postmortem drug concentrations.
• Evaluating inter-tissue concentration ratios as comparative indicators for toxicological interpretation.

Strengths

• Data covers concentrations in blood and nine tissues over a 96-hour period.
• Includes results from three distinct dose levels (low, medium, high).
• Postmortem conditions were controlled for two storage temperatures (4 °C and 20 °C).
• Analytical methods were validated using HPLC–MS/MS.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 47.9 KB, indicating a limited scope.

Provenance

Source

Lingxiao Wang via figshare

Collection Method

Experimental study in male rats with drug administration, tissue sampling, and HPLC–MS/MS analysis.

Freshness

Last updated 2026-03-18 07:36:08