Mouse Muscle Transcriptome Data on High-Fat Diet and Exercise Intervention

Transcriptomic data from a mouse study investigating the effects of an 8-week moderate-intensity continuous training intervention on high-fat diet-induced muscle wasting. The dataset was created by Weihao Hong and published on figshare in March 2026. It contains RNA sequencing results from gastrocnemius muscle tissue.

Use Cases

• Identify differentially expressed genes related to muscle atrophy based on the mention of Foxo1, Fbxo32, and Trim63.
• Analyze transcriptional programs for lipid metabolism based on described adaptations in fatty acid uptake, trafficking, and β-oxidation.
• Perform functional enrichment analysis on signaling pathways based on the description of FoxO, PI3K–Akt, MAPK, and insulin signaling.
• Investigate transcriptomic signatures of exercise intervention based on the comparison between high-fat diet and exercise groups.

Strengths

• Data is associated with a detailed experimental protocol described in the source, including 21 weeks of HFD feeding and an 8-week MICT intervention.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• The description provides specific biological findings, such as changes in muscle index, grip strength, and fiber cross-sectional area.

Limitations

• The dataset is very small at 16.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Weihao Hong.

Collection Method

RNA sequencing of mouse gastrocnemius muscle tissue from a controlled laboratory study.

Freshness

Last updated 2026-03-18 07:34:52; freshness should be verified.