Mouse Hippocampus Transcriptomics for Active Place Avoidance Memory

Isaac Vingan measured gene expression changes in the dorsal hippocampus of four mice three days after memory consolidation. Spatial transcriptomics and single nuclear RNA sequencing revealed regionally distributed synaptic function genes and reduced metabolic activity genes. The dataset, last updated in 2026, is available under a CC-BY-4.0 license.

Use Cases

• Identify region-specific gene expression patterns based on spatial transcriptomics data.
• Analyze transcriptomic signatures of synaptic plasticity based on differentially expressed genes.
• Compare gene expression in memory-associated neurons versus general hippocampal neurons based on Arc-Cre/flox-eYFP tagging.
• Investigate metabolic activity changes during offline memory maintenance based on down-regulated ATP synthesis genes.

Strengths

• Data includes results from both spatial transcriptomics and single nuclear RNA sequencing.
• Focuses on a specific time point (3 days post-memory consolidation) and a specific behavioral task (active place avoidance).
• Uses a transgenic mouse line (Arc-Cre/flox-eYFP) for targeted analysis of memory-associated neurons.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is small (4.2 MB), suggesting limited scale.

Provenance

Source

Isaac Vingan

Collection Method

Gene expression measured via spatial transcriptomics and single nuclear RNA sequencing in Arc-Cre/flox-eYFP transgenic mice.

Freshness

Last updated 2026-05-18 04:10:46; freshness should be verified.