TgF344 Rat Hippocampal Epigenetics and Histopathology After Treadmill Training

239 differentially modified regions in exercised female rats and 216 in males reveal sex-dependent epigenetic changes. This dataset contains hippocampal histopathology and DNA modification profiles from aged TgF344-AD rats following progressive treadmill-training, created by Adam J. Schuller and published on figshare in May 2026. Reduced-representation bisulfite sequencing and quantitative fluorescence microscopy data characterize glial activation and synaptic plasticity.

Use Cases

• Analyze sex-dependent epigenetic changes based on differentially modified cytosines (DMCs) and regions
• Investigate plaque-associated microglial reactivity state based on quantitative fluorescence microscopy data
• Study functional enrichment of pathways related to glial activation and synaptic plasticity
• Correlate physical exercise with neuronal and microglial density changes in aged AD models

Strengths

• 94 genes associated with DMCs in females and 87 in males provide a basis for sex-specific analysis
• 239 differentially modified regions in females and 216 in males offer a quantifiable epigenetic dataset
• CC-BY-4.0 license allows for open sharing and reuse

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is from a specific transgenic rat model (TgF344), limiting generalizability

Provenance

Source

Adam J. Schuller via figshare

Collection Method

Reduced-representation bisulfite sequencing and quantitative high-throughput slide scanning fluorescence microscopy

Freshness

Last updated 2026-05-05 15:19:08