U.S. Cardiovascular Mortality Trends in Rheumatoid Arthritis, 1999–2023

63,406 deaths from rheumatoid arthritis-related cardiovascular disease occurred among U.S. adults aged 25 and older from 1999 to 2023. The dataset contains age-adjusted mortality rates, annual percent change estimates, and demographic breakdowns by sex, region, race/ethnicity, and urbanicity. It was compiled by Ye Jiang using CDC WONDER mortality data and ICD-10 codes.

Use Cases

• Analyze demographic disparities in age-adjusted mortality rates (AAMR) by sex, region, and race/ethnicity to identify high-risk subgroups.
• Model temporal trends using annual percent change (APC) and average annual percent change (AAPC) estimates from joinpoint regression.
• Compare AAMR for ischemic heart disease against other cardiovascular disease types among individuals with rheumatoid arthritis.
• Investigate the relationship between urbanicity (rural vs. urban areas) and AAMR for RA-related cardiovascular mortality.

Strengths

• Documents 63,406 deaths over a 25-year period (1999–2023), providing a long-term trend analysis.
• Includes detailed demographic stratification by sex, U.S. Census region, race/ethnicity, and urban/rural classification.
• Reports age-adjusted mortality rates (AAMR) with 95% confidence intervals for key subgroups, enhancing statistical reliability.

Limitations

• The data is presented in a DOCX report (29.0 KB), not a structured table, limiting direct computational analysis.
• Specific row and column counts for the underlying data are unknown, as only summary statistics are provided.
• The analysis is limited to U.S. mortality data and may not reflect trends in other countries.

Provenance

Source

Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database.

Collection Method

Mortality data identified using International Classification of Diseases, 10th Revision (ICD-10) codes; age-adjusted rates calculated; joinpoint regression applied.

Time Range

1999 to 2023

Freshness

Data covers through 2023, with the analysis last updated in March 2026.

Geography

United States, with analysis by U.S. Census region and urban/rural classification.