Triptolide Effects on Staphylococcus Aureus Infection: Multi-Omics Data from Murine Models

Triptolide, a traditional Chinese medicine monomer, was identified as a facilitator of host immunity-mediated clearance of Staphylococcus aureus and MRSA. The dataset likely contains results from screening 41 TCM monomers and multi-omics analyses including transcriptomics, proteomics, metagenomics, and metabolomics from infected mice. Xinli Qiu published this 66.0 KB Excel file on figshare in May 2026.

Use Cases

• Identify potential host-directed therapy candidates based on screening results for 41 TCM monomers.
• Analyze the mechanism of triptolide action based on transcriptomic and proteomic data from infected macrophages.
• Study the impact of treatment on gut microbiota homeostasis based on metagenomic data from murine infection models.
• Investigate metabolic function changes in infected hosts based on metabolomic data.
• Validate the role of XIAP in host apoptosis for pathogen clearance using molecular dynamics simulation and biochemical assay results.

Strengths

• Data integrates results from multiple experimental methods: transcriptomics, proteomics, metagenomics, and metabolomics.
• The study includes a specific screening of 41 traditional Chinese medicine monomers.
• Findings are validated in a murine infection model, assessing bacterial load, inflammation, and pathology.

Limitations

• The dataset is small at 66.0 KB, suggesting limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Experimental research involving screening, molecular assays, and multi-omics analysis in cell and murine models.

Freshness

Last updated 2026-05-26 06:01:47; freshness should be verified.