Schistosoma Mansoni Egg Secretome from Mouse Liver and Intestine Granulomas

A dataset of 149 parasite proteins identified as the in vivo excretory/secretory repertoire of Schistosoma mansoni eggs. The data was generated by Lucie Jedličková using laser microdissection and mass spectrometry on granuloma microenvironments from infected mouse livers and intestines during acute and chronic infection phases. The dataset provides a snapshot of egg-derived proteins present within host tissues.

Use Cases

• Identify core parasite proteins involved in host modulation based on the conserved set of 149 proteins.
• Compare immunomodulator expression profiles based on data from acute versus chronic infection phases.
• Analyze organ-specific protein secretion patterns based on data from liver versus intestinal granulomas.

Strengths

• Identifies a core set of 149 parasite proteins from in vivo samples.
• Compares protein profiles across two organs (liver and intestine) and two infection phases (acute and chronic).
• Uses a specific methodology (laser microdissection and high-resolution mass spectrometry) detailed in the description.

Limitations

• The dataset is small (141.4 KB), suggesting limited scope or a summary-level view.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Laser microdissection of periovular granulomas from infected mouse tissues followed by mass spectrometry.

Freshness

Last updated 2026-05-15 05:47:22.