Autophagy Protein Expression in Adrenocortical Carcinoma by Tumor Stage

LC3B punctate staining was present in 89% of adrenocortical carcinoma (ACC) cases compared to 25% in adrenocortical adenomas (ACA). This dataset, authored by Sofia B. Oliveira and last updated in May 2026, contains immunohistochemistry results for autophagy-related proteins ATG5, LC3B, and p62/SQSTM1 across 49 tumor samples. It likely includes protein expression percentages correlated with ENSAT tumor stage and metastasis status.

Use Cases

• Correlating autophagy protein expression levels with tumor stage based on ENSAT classification mentioned in the description
• Investigating the relationship between LC3B expression and metastasis status in adrenocortical carcinoma
• Comparing protein marker expression between benign adenomas and malignant carcinomas
• Analyzing the impact of autophagic flux inhibition on cell migration and invasion in ACC cell lines

Strengths

• Includes data from 49 total tumor samples (20 ACA, 29 ACC), providing a basis for comparison
• Reports specific, statistically significant findings (e.g., LC3B expression 14.81% vs 2.05%, p < 0.0001)
• Correlates protein expression with clinically relevant staging (ENSAT) and metastasis outcomes

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small (671.0 KB), indicating limited scope

Provenance

Source

figshare

Collection Method

Immunohistochemistry on tumor samples and in vitro cell line assays.

Freshness

Last updated 2026-05-18 05:53:11; freshness should be verified