Interventions Affecting Next-Generation Epigenetic Aging Clocks in Humans

Adiv A. Johnson compiled a list of 41 human studies reporting the effects of interventions on next-generation epigenetic aging clocks. The dataset, last updated in May 2026, summarizes interventions that decrease, have no effect on, or accelerate epigenetic age. It includes pharmaceutical, lifestyle, supplementation, clinical, and psychosocial interventions.

Use Cases

• Comparing the efficacy of different longevity interventions based on reported effect sizes.
• Identifying promising pharmaceutical candidates for aging research based on positive results for drugs like semaglutide and pitavastatin.
• Analyzing the responsiveness of different next-generation epigenetic clocks to various intervention types.
• Prioritizing lifestyle factors for clinical trials based on evidence for interventions like exercise and a plant-rich diet.

Strengths

• Systematically identified 41 human studies, providing a focused evidence base.
• Explicitly focuses on next-generation clocks, which are more strongly associated with mortality risk than first-generation clocks.
• Covers a diverse range of intervention types including pharmaceutical, lifestyle, and supplementation.

Limitations

• Row count and specific column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small at 20.1 KB, indicating a summary or list format rather than raw experimental data.

Provenance

Source

figshare, authored by Adiv A. Johnson.

Collection Method

Compiled via systematic searches of human studies.

Freshness

Last updated 2026-05-28 22:03:23