Review of RING-Type E3 Ligases in Digestive System Tumor Progression and Therapy

A 136.7 KB review document summarizes the role of RING-type E3 ubiquitin ligases in digestive system cancers. Authored by Yuwei Wu and shared under a CC-BY-4.0 license on figshare, it was last updated on May 20, 2026. The text discusses these enzymes as tumor promoters or suppressors, their prognostic value, and potential as targets for small molecule inhibitors.

Use Cases

• Literature review on the mechanistic role of RING-type E3 ligases based on the described signaling pathways.
• Identifying potential prognostic biomarkers for digestive cancers based on the relationship between E3 ligase expression and patient outcomes discussed.
• Surveying recent research progress on anti-tumor small molecule inhibitors targeting specific E3 ligase classes as summarized in the document.

Strengths

• Document is shared under a permissive CC-BY-4.0 license, allowing broad reuse.
• The 136.7 KB file provides a focused review on a specific molecular mechanism in cancer.

Limitations

• The dataset is a single 136.7 KB DOCX file, indicating a very limited scope and scale.
• Row count and column-level documentation are absent; the content is a narrative review, not structured data.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Authored literature review.

Freshness

Last updated 2026-05-20 05:47:48; freshness should be verified.