PANDAS Autoantibody Screening Data from Nucleic Acid Protein Programmable Array

A study by Jelena Eremija employed the Nucleic Acid Protein Programmable Array (NAPPA) for unbiased screening of autoimmune targets in Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS). The dataset likely contains results comparing children with PANDAS to patients with autism spectrum disorder and healthy controls, identifying 1,235 non-overlapping protein targets initially and 117 autoantibody targets exclusive to PANDAS in a secondary screen. The data was uploaded to figshare on April 29, 2026.

Use Cases

• Identify potential autoimmune protein targets based on the 1,235 non-overlapping targets identified in the initial screen.
• Analyze the heterogeneity of autoantibody profiles based on the finding that 67.5% of PANDAS-positive targets were reactive in only a single patient.
• Evaluate the diagnostic utility of autoantibody signatures based on the description of poor performance in discriminating PANDAS from other groups.
• Perform functional enrichment analysis based on the described overrepresentation of targets among transcription factors, apoptosis regulators, and neural development proteins.

Strengths

• The dataset is derived from a specific, unbiased screening method (NAPPA) described in the study.
• The analysis includes comparisons across three distinct groups: PANDAS, autism spectrum disorder, and healthy controls.
• The description provides concrete numbers for identified targets (1,235 initial targets, 117 exclusive PANDAS targets).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description indicates autoantibody profiles were highly heterogeneous and diagnostic performance was poor, suggesting limited immediate clinical utility.

Provenance

Source

Jelena Eremija

Collection Method

Unbiased screening using the Nucleic Acid Protein Programmable Array (NAPPA) protein expression system.

Freshness

Last updated 2026-04-29 05:41:45; freshness should be verified.