Rat Model Metabolomic and Proteomic Data for Knee Osteoarthritis Acupuncture Study

Integrated metabolomic and proteomic data from a study of 40 rats evaluating homologous point acupuncture for knee osteoarthritis. The dataset, authored by Wu Liu and last updated in April 2026, compares behavioral scores, cytokine levels, and pathway analyses across control, disease model, and two treatment groups. Results suggest therapeutic mechanisms involve modulation of arachidonic acid metabolism and glycolytic processes.

Use Cases

• Compare inflammatory biomarker levels (IL-6, IL-1β, TNF-α, LDH) across treatment groups based on the described experimental results.
• Analyze pathway enrichment related to immunity and metabolism, such as arachidonic acid metabolism, mentioned in the study findings.
• Investigate correlations between behavioral assessments (Lequesne MG scores, joint swelling) and molecular profiles from the integrated omics data.
• Validate protein expression changes related to glycolysis, NLRP3 inflammasome activation, autophagy, and apoptosis as described in the Western blot analysis.

Strengths

• Data is derived from a controlled animal study with four distinct groups of 10 rats each, allowing for comparative analysis.
• Integrated multi-omics approach combines metabolomic and proteomic profiles to explore therapeutic mechanisms.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download to understand data structure.
• The dataset is very small at 73.6 KB, indicating limited scope, likely containing summary or processed results rather than raw sequencing data.
• Data is specific to a rat model, and direct translatability to human knee osteoarthritis may be limited.

Provenance

Source

figshare

Collection Method

Generated from a rat model study of knee osteoarthritis involving intra-articular injections, acupuncture treatments, and subsequent metabolomic/proteomic analysis.

Freshness

Last updated 2026-04-22 10:03:49