HIF-1 Pathway Gene Expression in PBMCs from Alzheimer's Patients and Controls

391 older individuals, including 83 Alzheimer's disease patients and 308 cognitively healthy controls, provided peripheral blood mononuclear cells for this study. Beatrice Arosio analyzed HIF1A and HIF1AN gene expression and their associations with inflammatory markers. The findings suggest altered HIF-1α signaling may reflect impaired cellular responsiveness linked to neuroinflammatory processes in Alzheimer's disease.

Use Cases

• Train classifiers to differentiate Alzheimer's patients from controls based on HIF1A and HIF1AN gene expression levels.
• Analyze correlations between HIF-1 pathway gene expression and inflammatory cytokine levels like IL-6, IL-1β, and TREM-1.
• Investigate the role of HIF1AN as a negative regulator of inflammatory gene expression in peripheral immune cells.
• Build models to predict plasma protein concentrations (e.g., IL-1β, soluble TREM-1) from PBMC gene expression data.

Strengths

• Includes data from 391 participants, a substantial cohort for a clinical study.
• Links gene expression in PBMCs to corresponding plasma protein concentrations for several inflammatory markers.
• Analysis adjusted for key covariates including age, sex, and Apolipoprotein E ε4 status.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal or source bias inherent to the specific study cohort.

Provenance

Source

Beatrice Arosio via figshare

Collection Method

Gene expression analysis of peripheral blood mononuclear cells (PBMCs) from a clinical cohort.

Freshness

Last updated 2026-06-03 05:40:07; freshness should be verified.