LIRE: Clinical Phenotypes of SLE Patients Initiating Belimumab

125 patients from the Lupus Italian REgistry (LIRE) initiating belimumab therapy were analyzed using Factor Analysis of Mixed Data (FAMD) and hierarchical clustering. The analysis identified four distinct clinical clusters based on 150 baseline variables, assessing disease activity and damage outcomes at 6 and 12 months. The dataset was authored by Mariele Gatto and last updated on 2026-05-28.

Use Cases

• Identify patient subgroups for targeted therapy based on clinical and laboratory variables.
• Assess the relationship between baseline clinical profiles and treatment response rates.
• Study the progression of organ damage in different SLE phenotypes under biologic therapy.
• Validate unsupervised machine learning methods for clinical phenotyping in rheumatology.

Strengths

• Includes data from 125 patients in a multicentric registry.
• Analysis based on 150 baseline clinical and laboratory variables.
• Clinical outcomes assessed at two time points (6 and 12 months).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (21.7 KB), indicating limited scope.

Provenance

Source

Lupus Italian REgistry (LIRE)

Collection Method

Data derived from a multicentric registry of patients starting belimumab added to standard treatment.

Freshness

Last updated 2026-05-28 06:20:43; freshness should be verified.

Geography

Italy