Prenatal Folate Supplementation Clinical Trial Results

Eighty pregnant participants were randomized in a 24-week trial comparing two prenatal multivitamin formulations. The study measured total folate and unmetabolized folic acid concentrations in maternal and fetal tissues across three time points. Thirty-one participants in each group completed the trial.

Use Cases

• Analyze differences in unmetabolized folic acid concentrations between the MTHF-MVI and FA-MVI groups in maternal blood and placental tissue.
• Compare total folate concentrations in maternal serum, cord serum, and placenta across the 0, 12, and 24-week study intervals.
• Evaluate the proportion of participants with detectable unmetabolized folic acid in cord blood samples from each supplementation group.
• Model the relationship between folate form supplementation and maternal/fetal folate status using trial outcome data.

Strengths

• Data originates from a randomized controlled trial with 80 initial participants, providing a structured experimental design.
• Measurements include multiple biological samples: maternal blood, cord blood, and placental tissue.
• Clinical trial is registered with ClinicalTrials.gov (NCT05673070), ensuring protocol transparency.

Limitations

• Small final sample size of 31 completers per group limits statistical power for some comparisons.
• Data scope is limited to a single 24-week trial, restricting longitudinal analysis beyond pregnancy.
• The dataset is very small (13.8 KB), indicating it contains summary or tabulated results, not raw individual-level data.

Provenance

Source

Fulvia Draicchio via figshare.

Collection Method

Randomized controlled trial with blood, cord, and placental sample collection.

Time Range

24-week intervention period during second and third trimesters of pregnancy.

Freshness

Last updated in March 2026.

Geography

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