Sea Urchin Immune Cell Transcriptional Response to UVB-Induced DNA Damage

Transcriptomic data from purple sea urchin Strongylocentrotus purpuratus immune cells exposed to UVB radiation. The dataset likely contains gene expression profiles from single-cell RNA sequencing at six hours post-exposure, identifying phagocytes and vibratile cells as key responders. Riss M. Kell published the data on figshare under a CC-BY-4.0 license, with a last update in March 2026.

Use Cases

• Identify conserved DDR gene activation based on transcriptional response data.
• Analyze autophagy pathway induction based on functional assay results mentioned.
• Compare innate immune pathway activation between cell types based on single-cell RNA sequencing.
• Investigate post-translational modification patterns in signaling pathways based on western blot data.
• Study the molecular framework for damage recognition in echinoderms based on the established framework.

Strengths

• Data is derived from a long-lived, cancer-resistant model organism diverged from vertebrates ~550 million years ago.
• Includes results from single-cell RNA sequencing, functional assays, and western blots.
• File size is 5.9 MB, indicating a manageable download.

Limitations

• Row count and column-level documentation are unknown.
• Data may reflect the specific experimental conditions of UVB exposure in sea urchin coelomocytes.

Provenance

Source

figshare

Collection Method

Experimental data from UVB exposure, single-cell RNA sequencing, functional assays, and western blots.

Freshness

Last updated 2026-03-19 05:18:31.