E. coli K1 Virulence Data: IbeA-Mediated Adhesion, Invasion, and Biofilm Formation

A 9.8 MB DOCX file from figshare, last updated April 16, 2026, authored by Bingliang Zhou. The data likely contains results from in vitro and in vivo experiments quantifying the role of the IbeA virulence factor in Escherichia coli K1 adhesion, invasion, and biofilm formation during blood-brain barrier traversal. The study establishes a mechanistic link between IbeA's functions and the Vimentin–NF-κB signaling pathway.

Use Cases

• Modeling bacterial adhesion and invasion dynamics based on quantified assays in human brain microvascular endothelial cells (HBMECs).
• Analyzing biofilm formation patterns based on crystal violet assay results from both biotic and abiotic surfaces.
• Investigating Vimentin–NF-κB signaling pathway activation based on data from immunofluorescence, co-immunoprecipitation, and pharmacological inhibition.
• Evaluating neurological outcomes and bacterial dissemination based on results from a neonatal rat meningitis model.

Strengths

• Data is associated with a detailed methodological description including TEER, confocal imaging, and crystal violet assays.
• Includes both in vitro (HBMEC) and in vivo (neonatal rat) experimental results.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The primary data is embedded within a 9.8 MB DOCX document, requiring extraction for computational analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental data generated from isogenic mutant generation, cell culture assays, and animal models.

Time Range

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Freshness

Last updated 2026-04-16 04:19:03; freshness should be verified.

Geography

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