Review of Virus-Driven Immune Remodeling and Response to Immune Checkpoint Inhibitors

Guangying Wang authored a review document summarizing the clinical application and immunological mechanisms of immune checkpoint inhibitors (ICIs) in patients with concurrent viral infections. The 35.3 KB document, last updated on 2026-04-27, is available under a CC-BY-4.0 license on figshare. It focuses on infections from HBV, HCV, HIV, HPV, and EBV and their impact on ICI efficacy, safety, and viral control.

Use Cases

• Literature review on the infection-immunity-cancer crosstalk based on the systematic summary of clinical evidence.
• Analysis of immunological mechanisms linking viral infections to ICI response heterogeneity based on described concepts of T cell exhaustion and TME remodeling.
• Informing treatment strategy development based on the proposed potential of virus-specific immune profiling for individualized therapy.
• Studying risks and management of viral reactivation during ICI therapy based on the highlighted concern in the context of immune-related adverse events.

Strengths

• Document is licensed under the permissive CC-BY-4.0 license, facilitating reuse.
• The review systematically summarizes current clinical applications across five specific viral infections (HBV, HCV, HIV, HPV, EBV).
• Last update timestamp is precisely recorded as 2026-04-27 05:16:29.

Limitations

• The dataset is a 35.3 KB DOCX file, indicating a very limited scope as a review document rather than primary data.
• Row count and column-level documentation are absent; the content's structure and data semantics must be inferred after download.
• The description is a review abstract; the actual data content and its format within the document require manual inspection.

Provenance

Source

Guangying Wang via figshare.

Collection Method

Authored review document summarizing existing clinical and immunological evidence.

Freshness

Last updated 2026-04-27 05:16:29.