Systematic Review of Vitamin D and Resveratrol Trials for Sarcopenic Obesity

A systematic review by Cristina Russo, registered with PROSPERO (CRD420261307248), searched PubMed, Scopus, and Web of Science for randomized controlled trials on vitamin D or resveratrol supplementation in adults with sarcopenic obesity. The search, conducted up to 2026, retrieved five records, but none met the strict eligibility criteria requiring baseline confirmation of both adiposity and sarcopenia.

Use Cases

• Identify gaps in clinical trial design based on the review's finding of zero eligible phenotype-defined RCTs.
• Inform future trial enrollment strategies based on the review's conclusion about the need for integrated adiposity and muscle dysfunction criteria.
• Guide mechanistic research on NF-κB signaling, PGC-1α, and mitochondrial regulation pathways mentioned in the review's background.

Strengths

• Systematic review protocol is registered with PROSPERO (CRD420261307248), providing a traceable methodology.
• Risk of bias was assessed using the Cochrane RoB 2.0 tool, a standard for clinical trial evaluation.
• The search was conducted across three major databases (PubMed, Scopus, Web of Science).

Limitations

• The dataset is a 13.6 KB DOCX document, not a structured data table, limiting computational analysis.
• The review found zero eligible trials, meaning it contains no primary interventional data.
• Row count and column-level documentation are absent, as the file is a textual review article.

Provenance

Source

figshare

Collection Method

Systematic dual-track literature search across PubMed, Scopus, and Web of Science.

Freshness

Last updated 2026-05-14.