Vitamin D Dynamics Predicting Glucocorticoid Response in Thyroid Eye Disease

52 patients with thyroid-associated ophthalmopathy (TAO) were studied retrospectively at the First Affiliated Hospital of Xi’an Jiaotong University from 2015 to 2019. The dataset includes pre- and post-treatment serum 25-hydroxyvitamin D levels and bone markers for patients receiving intravenous glucocorticoid therapy. Multivariate regression identified the change in vitamin D level as an independent predictor of treatment response, with an optimal cutoff increase of 2.7 ng/mL.

Use Cases

• Predicting patient response to intravenous glucocorticoid therapy based on baseline vitamin D levels and clinical scores.
• Identifying biomarker cutoffs for treatment success using ROC analysis on the change in serum 25(OH)D.
• Analyzing subgroup treatment efficacy in male, elderly, or vitamin D-deficient patient populations mentioned in the study.

Strengths

• Dataset includes 52 patient records with detailed clinical and laboratory measurements.
• Analysis identifies a specific, quantifiable predictor (Δ25(OH)D ≥ +2.7 ng/mL) for treatment response.
• Multivariate analysis adjusted for confounders, with reported odds ratios and confidence intervals.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data reflects a single-center, retrospective study from 2015-2019, which may limit generalizability.

Provenance

Source

Ling Wang, via figshare.

Collection Method

Retrospective cohort study of patients completing standardized therapy.

Time Range

2015–2019

Freshness

Last updated 2026-04 21 04:20:05; freshness should be verified.

Geography

First Affiliated Hospital of Xi’an Jiaotong University, China.