Working Memory Performance in T2DM Patients with MMSE-Defined Cognitive Status

Containing behavioral study results from 54 participants with type 2 diabetes mellitus (T2DM), classified into higher (n=29) and lower (n=25) cognitive status groups based on Mini-Mental State Examination (MMSE) scores. It records working memory performance using verbal and visuospatial N-back tasks (0-back to 2-back), measuring reaction time and accuracy under different cognitive load conditions. The data was collected between November 2023 and June 2024 from patients at the Department of Endocrinology, Affiliated Hospital of Yan’an University.

Use Cases

• Analyze the correlation between MMSE scores and 2-back accuracy in verbal and visuospatial tasks to model cognitive status associations.
• Compare reaction time and accuracy between the T2DM-HC and T2DM-LC groups across 0-back, 1-back, and 2-back conditions to assess working memory impairment.
• Examine the relationship between clinical variables like diabetes duration and HbA1c levels with N-back task performance within the participant groups.
• Use hierarchical regression to evaluate how much variance in global cognitive status is explained by including verbal 2-back accuracy versus visuospatial 2-back accuracy.

Strengths

• Data includes 54 participants with clearly defined groups (29 T2DM-HC, 25 T2DM-LC) based on MMSE scores.
• Measures working memory performance across multiple cognitive load conditions (0-back to 2-back) for both verbal and visuospatial domains.
• Records key clinical variables such as diabetes duration, HbA1c levels, and number of comorbidities for correlation analysis.
• Study design includes partial correlation and hierarchical regression analyses, with specific results reported (e.g., ΔR² values of 0.189 and 0.386).

Limitations

• Small sample size of 54 participants limits statistical power and generalizability of findings.
• Cross-sectional design from a single hospital in China prevents causal inference and may introduce geographic bias.
• Data is presented in a DOCX document (53.5 KB), not a structured tabular format, requiring extraction for computational analysis.

Provenance

Source

Hongyan Bian, via figshare.

Collection Method

Participants were recruited from the Department of Endocrinology at the Affiliated Hospital of Yan’an University. Working memory was assessed using N-back tasks; reaction time and accuracy were recorded.

Time Range

November 2023 to June 2024.

Freshness

Data collected between November 2023 and June 2024; last updated on the platform in March 2026.

Geography

China (Yan’an University Affiliated Hospital).