WSTF and GLYCTK Regulation in Colorectal Cancer: Multi-Omics Analysis

Liming Zhou's dataset, shared on figshare in April 2026, contains results from a multi-omics study of Williams syndrome transcription factor (WSTF) and its candidate downstream target GLYCTK in colorectal cancer. The 792.0 KB Excel file likely contains integrated transcriptomic, metabolomic, and ChIP-seq analysis results from CRC cells and patient cohorts. The data supports findings on WSTF's role in metabolic adaptation and GLYCTK's association with CRC risk and immune-cold tumor microenvironments.

Use Cases

• Identify candidate biomarkers for colorectal cancer based on the described inverse association between WSTF and GLYCTK expression.
• Investigate metabolic pathway alterations in cancer using the described transcriptomic and metabolomic reprogramming data.
• Explore drug-target interactions for compounds like phenylbiguanide and hydroxyfasudil identified in the associated drug screening.
• Analyze immune infiltration patterns in tumors based on the described association of GLYCTK with an immune-cold microenvironment.

Strengths

• Dataset integrates multiple omics layers (transcriptomic, metabolomic, ChIP-seq) as described in the study methods.
• Includes results from functional assays (proliferation, migration, invasion) and drug screening mentioned in the description.
• Shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is small (792.0 KB), indicating limited scope, likely containing summary results rather than raw experimental data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Liming Zhou.

Collection Method

Integrated multi-omics analysis from CRC cell lines and patient cohorts, including RNA-seq, LC-MS metabolomics, ChIP-seq, and SMR analysis.

Freshness

Last updated 2026-04-23 09:48:02; freshness should be verified.