XIST Expression and X-Chromosome Hypermethylation in Male SLE Patients

A multi-omic dataset from the whole blood of 720 Systemic Lupus Erythematosus patients and 84 healthy controls. The data was collected by Helen O. Masson and last updated on figshare in April 2026. It focuses on identifying sex-specific molecular features, particularly aberrant XIST expression and X-chromosome hypermethylation in males with SLE.

Use Cases

• Identify sex-specific molecular signatures in SLE based on differential expression analysis between male and female patients.
• Investigate the correlation between XIST expression levels and disease severity in male SLE patients.
• Analyze X-chromosome hypermethylation patterns and their link to transcriptional silencing of X-linked genes.
• Explore the interaction effects between sex and disease status using a factorial design from multi-omic data.

Strengths

• Includes data from 804 total subjects (720 SLE patients, 84 healthy controls).
• Integrates epigenomic, transcriptomic, and proteomic data modalities for multi-omic analysis.
• Analysis uses a factorial design and Benjamini & Hochberg false discovery rate correction for statistical rigor.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 29.6 KB, indicating limited scope or summary-level data.

Provenance

Source

Helen O. Masson via figshare.

Collection Method

Leveraging epigenomic, transcriptomic, and proteomic data from whole blood samples.

Time Range

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Freshness

Last updated 2026-04-09 08:48:14; freshness should be verified.

Geography

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