ZFP36L1 and Autophagy in Murine Norovirus Replication: Experimental Results

A research paper from figshare, authored by Malabika Bhowmik and last updated in April 2026, investigates the antiviral role of the RNA-binding protein ZFP36L1 against norovirus. The 59.1 KB PDF presents experimental results using murine norovirus 1 (MNV-1) as a model, showing ZFP36L1 suppresses viral replication by negatively regulating autophagy. The dataset is published under a CC-BY-4.0 license.

Use Cases

• Study the antiviral effects of ZFP36L1 based on overexpression and knockdown experiments described.
• Investigate the relationship between autophagy and norovirus replication based on markers like ATG13 and LC3 conversion.
• Analyze gene expression changes in autophagy-related pathways based on mentions of ATG13, Beclin-1, and Bcl-2.
• Model host-virus interactions for norovirus based on the described experimental system using MNV-1.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.
• The description provides a detailed account of the experimental methodology and key findings.
• The source file is a small PDF (59.1 KB), ensuring easy download and storage.

Limitations

• The dataset is a single 59.1 KB PDF document, representing a very limited scope of raw data.
• Column-level documentation is absent; field semantics must be inferred from the paper text after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Malabika Bhowmik.

Collection Method

Likely contains experimental results from virology and molecular biology research.

Freshness

Last updated 2026-04-21 09:23:42; freshness should be verified.