ZNF473 Gene Expression and Prognostic Associations Across Cancer Types

16.4 KB of bioinformatics analysis results investigating Zinc finger protein 473 (ZNF473) as a biomarker. The data, authored by Yifan Ren and last updated in May 2026, includes findings from integrated bioinformatics and experimental validation, showing ZNF473 was significantly upregulated in more than 10 cancer types and had prognostic associations in four cancer types, with a focus on hepatocellular carcinoma.

Use Cases

• Identify cancer types with significant ZNF473 upregulation based on differential expression analysis mentioned in the description
• Assess the diagnostic performance of ZNF473 using ROC curve analyses yielding an AUC exceeding 0.7 in 19 cancer types
• Evaluate prognostic associations of ZNF473 expression via Kaplan–Meier and Cox regression analyses identified in four cancer types
• Investigate correlations between ZNF473 expression and immune cell infiltration profiles or molecular subtypes as indicated by the Tumor–Immune System Interaction Database

Strengths

• Analysis covers more than 10 cancer types, providing a broad comparative view
• Includes experimental validation from in vitro and in vivo models supporting the bioinformatics findings
• Results are associated with specific clinical outcomes, such as unfavorable clinicopathological features in hepatocellular carcinoma

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The primary data file is a 16.4 KB DOCX document, which suggests the dataset is very small and likely contains summary results rather than raw data

Provenance

Source

figshare

Collection Method

Integrated bioinformatics analyses combined with cell-based experimental validation

Freshness

Last updated 2026-05-15 04:27:24; freshness should be verified