Plasma Exosomal Proteins in Intrahepatic Cholestasis of Pregnancy

SWATH proteomics data identifies differentially expressed proteins in plasma exosomes from pregnant women with intrahepatic cholestasis. The dataset includes quantitative profiles from 35 pregnant women, comprising 10 moderate ICP, 10 severe ICP, and 15 healthy controls. The analysis was conducted by Yuxuan Jiang and published on figshare in April 2026.

Use Cases

• Identify diagnostic biomarkers for ICP severity based on differentially expressed proteins in total exosomes.
• Investigate complement activation and coagulation pathways in ICP pathology using bioinformatics analysis.
• Validate hub protein candidates like HRG, VWF, and PIGR for potential involvement in disease pathogenesis.

Strengths

• SWATH proteomics identified 109 differentially expressed proteins in total exosomes and 46 in placenta-derived exosomes.
• Includes data from 35 pregnant women, with 20 ICP cases stratified by severity.
• Hub proteins HRG, VWF, and PIGR were identified and verified by Western blotting.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific cohort studied.

Provenance

Source

figshare

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:54; freshness should be verified.