aMAP Score and Mortality in MASLD/MetALD/ALD Patients: NHANES Cohort Study 1999-2018

A cohort study from 1999 to 2018 using National Health and Nutrition Examination Survey (NHANES) data, analyzing 32,654 participants to assess the association between the aMAP risk score and mortality in patients with steatotic liver disease. The research was authored by Peng-yang Li and published on figshare under a CC-BY-4.0 license. It includes external validation using an independent hospital-based Southern Chinese cohort of 642 individuals.

Use Cases

• Validate the aMAP score as a non-invasive mortality predictor based on the described cohort study results.
• Conduct risk stratification for patients with MASLD, MetALD, or ALD based on the reported hazard ratios.
• Model non-linear relationships between risk scores and outcomes using the restricted cubic spline analysis mentioned.
• Perform external validation of clinical risk tools using independent cohorts, as demonstrated in the description.

Strengths

• Includes a large primary cohort of 32,654 participants from a national survey (NHANES).
• Provides external validation with an independent cohort of 642 individuals.
• Analyzes multiple mortality outcomes: all-cause, cardiovascular, and cancer.
• Reports specific hazard ratios for MASLD (HR: 1.11), MetALD (HR: 1.39), and ALD (HR: 1.87).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data table is unknown, which may limit suitability assessment.
• The dataset is very small (19.7 KB), suggesting it may contain summary results rather than the underlying raw patient data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an independent hospital-based Southern Chinese cohort.

Collection Method

Cohort study using multivariable Cox models, restricted cubic spline analysis, and Kaplan–Meier curves.

Time Range

1999 to 2018 (NHANES data), with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-04-24 13:49:16; freshness should be verified.

Geography

United States (NHANES) and Southern China (validation cohort).