Influenza A(H1N1) Hemagglutinin Mutations and Co-Detection Records (2000–2025)

An integrated evidence-mapping synthesis of H1N1 research, covering 11,848 unique publications and GenBank-derived hemagglutinin sequences from 2000 to 2025. The dataset was created by Xinrui Cao and includes expert-curated mutational patterns, structural features, and literature-derived co-detection records. It was last updated in March 2026.

Use Cases

• Identify recurrent hemagglutinin substitutions like S13, S146, S160, and S202 to study post-2010 mutational shifts.
• Analyze literature-derived co-detection records to compare reported frequencies of pathogens like RSV and SARS-CoV-2.
• Examine the conformationally flexible HA segment spanning residues aa190–aa226 for structural analysis of the receptor-binding microenvironment.
• Investigate expert-prioritized mutations such as G219A in Eurasian avian-like H1N1 strains for hypothesis generation.
• Map the evolution of H1N1 research topics and surveillance priorities over a 25-year period using bibliometric data.

Strengths

• Integrates data from 11,848 unique publications, providing a broad literature base.
• Covers a 25-year time range (2000–2025) for longitudinal analysis of viral evolution.
• Includes expert-guided curation and structure-informed interpretation of hemagglutinin sequences.

Limitations

• The dataset is very small at 12.9 KB, indicating limited raw data or highly summarized content.
• Co-detection records are derived from heterogeneous study reports and do not represent population-level prevalence.
• Geographic coverage is biased, with a specific module focused on China, limiting global generalizability.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis of PubMed, Web of Science, and Scopus, expert curation, and analysis of GenBank HA sequences.

Time Range

2000–2025

Freshness

Last updated March 2026.

Geography

Global with a specific China-focused module; spatial coverage is not uniform.