Macrolide Resistance Trajectories in Bordetella Pertussis Across Three Genetic Backgrounds

Three clinical macrolide-susceptible Bordetella pertussis isolates were subjected to stepwise erythromycin exposure. The dataset includes phenotypic readouts such as antimicrobial susceptibility testing, growth and biofilm assays, and ELISA measurements of virulence factors. It was authored by Kaichong Jiang and last updated on 2026-04-17.

Use Cases

• Modeling antibiotic resistance trajectories based on genetic background and phenotypic readouts.
• Analyzing correlations between genomic alterations and phenotypic changes like growth and biofilm formation.
• Comparing virulence factor expression (PT, FHA, LPS, DHFS, DHFR) under antibiotic pressure across different strains.

Strengths

• Data tracks three distinct clinical genetic backgrounds, enabling comparative analysis.
• Includes multiple phenotypic assays: antimicrobial susceptibility, growth, biofilm, and ELISA.
• Licensed under CC-BY-4.0, permitting open reuse and modification.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is small at 16.3 KB, indicating a limited experimental scope.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Stepwise erythromycin induction of three clinical isolates, with tracking via whole-genome sequencing and phenotypic assays.

Freshness

Last updated 2026-04-17 05:20:53; freshness should be verified.