Mouse Lung Proteome Data for Millettia Speciosa Asthma Treatment Study

A proteomic dataset from a 2026 study investigating the therapeutic effects of Niudali (Millettia speciosa) in an ovalbumin-induced mouse model of allergic asthma. The dataset includes analysis of 179 differentially expressed proteins and cytokine profiles from bronchoalveolar lavage fluid. It was authored by Hangrui Yang and shared under a CC-BY-4.0 license.

Use Cases

• Identify key protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24-eosinophil axis in allergic inflammation using the cytokine and proteomic profiles.
• Analyze immunometabolic pathway modulation, such as PPAR signaling and lipid transport, as described in the functional enrichment results.
• Validate hub protein networks involving Alb, Apoe, and Apoa1 for their role in immune regulation and metabolic homeostasis.

Strengths

• Dataset is based on high-resolution data-independent acquisition (DIA) proteomics, a detailed analytical method.
• Includes specific findings on 179 differentially expressed proteins and the complete suppression of CCL24.
• Linked cytokine profiling shows significant reductions in IgE, IL-4, IL-5, and IL-6, corroborating proteomic results.

Limitations

• The dataset is very small at 465.0 B, indicating limited scope or summary-level data.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The proposed link to the gut-lung axis is noted as hypothetical and not directly investigated in the study.

Provenance

Source

figshare, author Hangrui Yang.

Collection Method

Generated from a controlled laboratory study using an ovalbumin-induced mouse model and DIA lung proteomics.

Freshness

Last updated 2026-06-03 07:42:26.